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Location: Boston, Massachusetts 02210
Employment Type: Contract
Job Description
Title: Crystallization Research Scientist
Location: Boston, MA
Work Arrangement: Onsite
Employment Type: Contract
Duration: 12+ months
About the Role
We are seeking a Crystallization Research Scientist to support drug substance process development at the laboratory and bench scale, with a strong focus on small-molecule API crystallization and particle engineering.
This role will develop and demonstrate early fit-for-purpose crystallization processes that can evolve into commercially viable API particle-forming processes. The work will include crystallization, isolation, drying, size reduction, and related particle engineering operations.
Key Responsibilities
Key Skills
API Crystallization | Small Molecule Process Development | Particle Engineering | Drug Substance | Process Scale-Up | DOE | QbD | HPLC | Raman | FBRM | XRPD | Chemical Engineering
Compensation
In accordance with applicable pay transparency requirements, the anticipated hourly rate for this role is $54.00–$60.00/hr, based on experience and qualifications.
Location: Boston, MA
Work Arrangement: Onsite
Employment Type: Contract
Duration: 12+ months
About the Role
We are seeking a Crystallization Research Scientist to support drug substance process development at the laboratory and bench scale, with a strong focus on small-molecule API crystallization and particle engineering.
This role will develop and demonstrate early fit-for-purpose crystallization processes that can evolve into commercially viable API particle-forming processes. The work will include crystallization, isolation, drying, size reduction, and related particle engineering operations.
Key Responsibilities
- Support laboratory-scale drug substance process development
- Develop and optimize small-molecule API crystallization processes
- Support particle engineering activities including crystallization, isolation, drying, and size reduction
- Apply chemistry and chemical engineering fundamentals to process development and scale-up
- Design and execute experiments to understand and optimize process parameters
- Use analytical and process characterization tools to evaluate material and process performance
- Collaborate with organic, physical, and analytical chemists, project teams, and manufacturing personnel
- BS or MS degree in a life science discipline, preferably Chemical Engineering or Chemistry
- 2–5 years of pharmaceutical industry experience
- Experience with API process development and scale-up
- Hands-on experience with small-molecule crystallization and particle engineering
- Strong understanding of chemistry and chemical engineering fundamentals, including kinetics, thermodynamics, and transport phenomena
- Experience with laboratory instrumentation such as HPLC, GC, FTIR, Raman, FBRM, DSC, TGA, or XRPD
- Strong written and verbal communication skills
- Ability to work effectively within multidisciplinary scientific teams
- Experience with statistical Design of Experiments (DOE)
- Familiarity with Quality by Design (QbD) concepts
- Experience with laboratory automation tools
- Familiarity with process or physical property modeling tools such as Aspen, Dynochem, or MATLAB
- Experience developing scalable particle-forming processes for pharmaceutical drug substances
Key Skills
API Crystallization | Small Molecule Process Development | Particle Engineering | Drug Substance | Process Scale-Up | DOE | QbD | HPLC | Raman | FBRM | XRPD | Chemical Engineering
Compensation
In accordance with applicable pay transparency requirements, the anticipated hourly rate for this role is $54.00–$60.00/hr, based on experience and qualifications.